{"product_id":"alidya-10ml","title":"ALIDYA - 5 vials of 10ml","description":"\u003cp\u003eALIDYA is a revolutionary new device for the treatment of cellulite.\u003c\/p\u003e\u003cp\u003e\u003cem\u003e* The application of the product is reserved exclusively for professional healthcare operators with adequate qualifications.\u003c\/em\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003e\u003cem\u003eMEDICAL DEVICE\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eAlidya\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e is the first injectable solution for the treatment of cellulite, i.e., an injectable solution for specific medical use applied according to a protocol involving intradermotherapy, which addresses the physiological and para-physiological alterations linked to the origin and evolution of gynoid lipodystrophy (cellulite). It was developed by Prof. Pasquale Motolese and is patented worldwide. Indications: treatment of gynoid lipodystrophy (cellulite), post-liposuction treatment, post-intralipotherapy, lymphedema with or without lipoedema, alterations of subcutaneous adipose tissue.\u003c\/span\u003e\u003c\/p\u003e\u003cp\u003e\u003cspan\u003eThe \u003c\/span\u003e\u003cstrong\u003e\u003cspan\u003eAlidya\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e project aims to provide an assistive rather than merely functional therapy by using means to correct changes in the structure of the skin and subcutaneous tissues for lipodystrophy and hypotrophy. In reality, these changes manifest clinically as small negative depressions or indentations on the skin surface, leading to uneven and cracked skin.\u003c\/span\u003e\u003c\/p\u003e\u003cp\u003e\u003cspan\u003eCorrecting these skin depressions or indentations on the skin surface is not possible with existing absorbent fillers available on the market. Attempts with polyactic acid have failed, as it proved to be highly reactive and profibrotic, leading to significant creation of scar tissue. In practice, it is very difficult to make corrections with gelatinous and highly viscous products that release microparticles.\u003c\/span\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eAlidya\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e, with its special formulation, is intended for superficial \u003cstrong\u003esubcutaneous\u003c\/strong\u003e tissues and differs from other products because it also acts on deeper parts of the skin, such as the dermis. Alydia represents a new class of injectable amino acid-based agents similar to those already on the market and used for skin rejuvenation (Jalupro, Skinr..). The difference is that Alidya's formulation is better suited to the biological environment, whether it be a superficial subcutaneous part or a deeper part of the skin.\u003c\/span\u003e\u003c\/p\u003e\u003cp\u003e\u003cimg class=\"img-responsive\" src=\"https:\/\/ramita.rs\/en\/slike\/alidya\/alidya-1.jpg\" alt=\"Alidya\"\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eAlydia\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e is a solution for injections into the outer subcutaneous part of the skin, containing rapidly absorbed components (within a few hours) that do not contain pharmacologically active substances.\u003c\/span\u003e\u003c\/p\u003e\u003cp\u003e\u003cspan\u003eAlthough there is no other product with a similar specific indication, there is a vast number of products with a similar composition that are used for the purpose of skin biorevitalization and biorestruction. The difference between these products and Alidya is that Alidya's formulation is adapted to osmolarity and pH values in different environments, not just those within the dermis.\u003c\/span\u003e\u003c\/p\u003e\u003ch2\u003e\u003cspan\u003eMedical evaluation\u003c\/span\u003e\u003c\/h2\u003e\u003cp\u003e\u003cspan\u003eClinical research conducted on women aged between 28 and 65 years showed excellent tolerability of the injectable agents with no skin reactions of any kind. Furthermore, the initial research (35 women treated once a week for 7 weeks) showed a high degree of satisfaction among the interviewed women, with a desire to repeat the treatment as soon as possible.\u003c\/span\u003e\u003c\/p\u003e\u003ch2\u003e\u003cspan\u003eAlidya\u003c\/span\u003e\u003c\/h2\u003e\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eAlidya\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e is the first injectable solution for the treatment of cellulite, i.e., an injectable solution for specific medical use applied according to a protocol involving intradermotherapy, which addresses the physiological and para-physiological alterations linked to the origin and evolution of gynoid lipodystrophy (cellulite). It was developed by Prof. Pasquale Motolese and is patented worldwide. Indications: treatment of gynoid lipodystrophy (cellulite), post-liposuction treatment, post-intralipotherapy, lymphedema with or without lipoedema, alterations of subcutaneous adipose tissue.\u003c\/span\u003e\u003c\/p\u003e\u003ch2\u003e\u003cspan\u003eAlidya – eliminates cellulite and provides permanent results\u003c\/span\u003e\u003c\/h2\u003e\u003cp\u003e\u003cspan\u003eBy definition, cellulite is a phenomenon that causes a chain of negative physical and psychological reactions.\u003c\/span\u003e\u003c\/p\u003e\u003cp\u003e\u003cspan\u003eThe medical name for cellulite is \"ADIPOSIS EDEMATOSA\".\u003c\/span\u003e\u003c\/p\u003e\u003cp\u003e\u003cspan\u003eThe development of cellulite is slow and proceeds in phases:\u003c\/span\u003e\u003c\/p\u003e\u003cul\u003e\n\n\u003cli\u003e\n\n\u003cstrong\u003e\u003cspan\u003eVenous and lymphatic pathway phase:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Altered microcirculation and small blood vessels spread in the deep tissue of the dermis;\u003c\/span\u003e\n\n\u003c\/li\u003e\n\n\u003cli\u003e\n\n\u003cstrong\u003e\u003cspan\u003eEdematous phase:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e The drainage system begins to function more slowly, and waste materials are retained within the interstitial space. This causes fluid to pass through the blood vessels into the tissues, leading to the development of edema. The interstitial space widens, suppresses its contents, and decreases drainage, creating a vicious circle;\u003c\/span\u003e\n\n\u003c\/li\u003e\n\n\u003cli\u003e\n\n\u003cstrong\u003e\u003cspan\u003eProliferative phase:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e The irregularities that occur disrupt the regular flow of nutrients and oxygen. Malnourished cells undergo changes in number and size, glycosaminoglycan production increases, appears to be of a more viscous consistency, and elastic fibers harden, forming a reticulum with the appearance of shapeless adipocytes that collect in nodes on the surface;\u003c\/span\u003e\n\n\u003c\/li\u003e\n\n\u003cli\u003e\n\n\u003cstrong\u003e\u003cspan\u003eSclerosis phase:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Here, more palpable nodes are present, there is a reaction and creation of fibrotic scars that pull round formations of the dermis, causing orange peel skin, i.e., the characteristic appearance of cellulite.\u003c\/span\u003e\n\n\u003c\/li\u003e\n\n\n\u003c\/ul\u003e\u003cp\u003e\u003cspan\u003eStudies by Dr. Motolese published in the European Journal of Aesthetic Medicine Dermatology at the end of 2011 address the pathophysiological causes of cellulite formation. The most widespread hypothesis concerns the anatomical pattern of adipose lobules located in the outer area of the subcutaneous adipose tissue, which becomes inflamed and determines the initial stage (obstruction), increasing microcirculatory permeability. The identification of potentially toxic elements could be a cause of tissue fibrosis.\u003c\/span\u003e\u003c\/p\u003e\u003cp\u003e\u003cspan\u003eThree tissue biopsies taken from three different women showed traces of certain metals, thus it is presumed that this is due to the presence of toxic intra-adipose metals linked to tissue degeneration, which develops into cellulite.\u003c\/span\u003e\u003c\/p\u003e\u003cp\u003e\u003cspan\u003eThe significance of cellulite refers to its aesthetic appearance, which is primarily observed in the female population, where changes in skin profile occur, especially in the lower limbs. Its nature is complex and controversial; therefore, despite limited scientific evidence, three pathogeneses are described:\u003c\/span\u003e\u003c\/p\u003e\u003cul\u003e\n\n\u003cli\u003e\u003cspan\u003eCirculatory disturbance causing microvascular pathways in the subcutaneous adipose tissue, linked to:\u003c\/span\u003e\u003c\/li\u003e\n\n\u003cli\u003e\u003cspan\u003eFemale hormonal factors, which have an impact on chronic tissue inflammation,\u003c\/span\u003e\u003c\/li\u003e\n\n\u003cli\u003e\u003cspan\u003eStructural anatomical defect involving the presence of administrative fibrotic septa on the skin surface, with an angled orientation of adipose lobules (in men, the orientation is parallel to the skin surface).\u003c\/span\u003e\u003c\/li\u003e\n\n\n\u003c\/ul\u003e\u003cp\u003e\u003cimg class=\"img-responsive\" src=\"https:\/\/ramita.rs\/en\/slike\/alidya\/alidya-2.jpg\" alt=\"Celulit\"\u003e\u003c\/p\u003e\u003cp\u003e\u003cspan\u003eDuring the research, biopsies were conducted on the anterolateral cellulite thighs of three women aged 33, 35, and 40, to determine the presence of \"ferritin-like\" matter in the extracellular matrix of the adipose tissue region. The degree of cellulite could be classified between III-IV.\u003c\/span\u003e\u003c\/p\u003e\u003cp\u003e\u003cspan\u003eMicroscopic examination showed that the adipose tissue consisted of cells of different sizes surrounded by a large area of sclerosis, with a strong presence of iron and hemosiderin.\u003c\/span\u003e\u003c\/p\u003e\u003cp\u003e\u003cspan\u003eIt is concluded that in the presence of these metals, tissue degeneration occurs through the creation of free radicals, peroxidation of lipid adipocyte membranes creating chronic inflammation, and tissue acidosis.\u003c\/span\u003e\u003c\/p\u003e\u003cp\u003e\u003cspan\u003eThis enlargement will result from vascular permeability, which can be seen in cellulite, and iron will exert its toxic and degenerative effects on subcutaneous adipose tissue, causing an inflamed state, acidosis, cell degeneration, and necrosis. It will gradually arise and cause continuous damage.\u003c\/span\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eAlidya\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e treatment promotes the removal of chelated iron produced by EDTA and the amino acid buffer solution with sodium bicarbonate corrector to compensate for the alkaline environment and with it, the cellulitic tissue acidosis.\u003c\/span\u003e\u003c\/p\u003e\u003ch2\u003e\u003cspan\u003eALIDYA composition\u003c\/span\u003e\u003c\/h2\u003e\u003cul\u003e\n\n\u003cli\u003e\u003cspan\u003ePoly-amino acid gel\u003c\/span\u003e\u003c\/li\u003e\n\n\u003cli\u003e\u003cspan\u003eα 1-4 glycoside\u003c\/span\u003e\u003c\/li\u003e\n\n\u003cli\u003e\u003cspan\u003eEDTA\u003c\/span\u003e\u003c\/li\u003e\n\n\u003cli\u003e\u003cspan\u003eAmino acid buffer composition with sodium bicarbonate correction, osmolarity regulator\u003c\/span\u003e\u003c\/li\u003e\n\n\u003cli\u003e\u003cspan\u003eD-glucopyranose: cyclic glucose generates the intermolecular reaction of the alcoholic carbonyl group, forming the pyranose form of glucose.\u003c\/span\u003e\u003c\/li\u003e\n\n\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eEffect:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e A mixture of amino acids, metal chelator, alkalized system connected with the extracellular space can create equilibrium, returning the adipose tissue structure to normal.\u003c\/span\u003e\u003c\/p\u003e\u003cp\u003e\u003cspan\u003eUsage:\u003c\/span\u003e\u003c\/p\u003e\u003cul\u003e\n\n\u003cli\u003e\u003cspan\u003eIntradermal: mesotherapy or 30G – 4mm needle, at least 7 applications per week, maximum 12 weeks\u003c\/span\u003e\u003c\/li\u003e\n\n\u003cli\u003e\u003cspan\u003eAfter application, apply drainage\u003c\/span\u003e\u003c\/li\u003e\n\n\u003cli\u003e\u003cspan\u003eDo not use cosmetics on the application area for at least 12 hours after treatment\u003c\/span\u003e\u003c\/li\u003e\n\n\u003cli\u003e\u003cspan\u003eDo not expose to high heat and\/or cold.\u003c\/span\u003e\u003c\/li\u003e\n\n\n\u003c\/ul\u003e","brand":"MARLLOR BIOMEDICAL","offers":[{"title":"Default Title","offer_id":51142991249674,"sku":"2014","price":78.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0840\/6718\/9002\/files\/alidya-5-fiale-da-10ml-9086081.jpg?v=1774707560","url":"https:\/\/mrfiller.com\/en-fr\/products\/alidya-10ml","provider":"Mr. Filler","version":"1.0","type":"link"}